Scientific breakthroughs rarely come from giant steps. Rather, it’s a continuous progression of small steps and astute application of those differences that enables advances. The ORCA-Flash4.0 V2 is the perfect examples of this process. From its introduction the ORCA-Flash4.0 has challenged the status quo of imaging and undergone a series of useful enhancements. The most recent is perhaps the most exciting; a notable increase in the ability to detect photons. This enhanced QE means that you have a possibility of detecting the faintest of signals. Or, for moderately dim samples, that the ideal image is achievable with shorter exposure times, perhaps saving your cells from phototoxicity or bleaching. With the ORCA-Flash4.0 V2 already delivering wide field of view, large dynamic range, and fast frame rates, this QE enhancement only makes it more versatile and powerful.